Hiroshi Kawachi Selected Research

nephrin

1/2021	Synbindin Downregulation Participates in Slit Diaphragm Dysfunction.
1/2020	Partitioning-Defective-6-Ephrin-B1 Interaction Is Regulated by Nephrin-Mediated Signal and Is Crucial in Maintaining Slit Diaphragm of Podocyte.
1/2017	PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease.
10/2016	Possible role for glomerular-derived angiotensinogen in nephrotic syndrome.
3/2016	Role of calcineurin (CN) in kidney glomerular podocyte: CN inhibitor ameliorated proteinuria by inhibiting the redistribution of CN at the slit diaphragm.
12/2014	Angiotensin II type 1 receptor blockade ameliorates proteinuria in puromycin aminonucleoside nephropathy by inhibiting the reduction of NEPH1 and nephrin.
8/2014	Therapeutic target for nephrotic syndrome: Identification of novel slit diaphragm associated molecules.
6/2012	Early treatment with everolimus exerts nephroprotective effect in rats with adriamycin-induced nephrotic syndrome.
4/2010	p21-activated kinases regulate actin remodeling in glomerular podocytes.
10/2009	Tolvaptan, a selective oral vasopressin V2 receptor antagonist, ameliorates podocyte injury in puromycin aminonucleoside nephrotic rats.

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Hiroshi Kawachi Research Topics

Disease

61	Proteinuria 01/2021 - 04/2002
28	Glomerulonephritis 01/2022 - 05/2001
23	Neoplasms (Cancer) 08/2022 - 07/2007
16	Fibrosis (Cirrhosis) 10/2021 - 10/2004
16	Nephrotic Syndrome (Syndrome, Nephrotic) 01/2020 - 01/2002
9	Albuminuria 10/2021 - 05/2002
7	Breast Neoplasms (Breast Cancer) 02/2022 - 01/2008
7	Rectal Neoplasms (Rectal Cancer) 01/2022 - 03/2017
7	Lipoid Nephrosis (Glomerulonephritis, Minimal Change) 01/2021 - 08/2006
7	Chronic Renal Insufficiency 11/2019 - 10/2004
7	Body Weight (Weight, Body) 12/2014 - 04/2002
6	Diabetic Nephropathies (Diabetic Nephropathy) 01/2017 - 01/2003
6	Nephritis 04/2016 - 11/2002
6	Renal Insufficiency (Renal Failure) 10/2013 - 10/2004
6	Inflammation (Inflammations) 09/2013 - 02/2004
6	Nephrosis 04/2010 - 04/2003
5	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 10/2021 - 04/2006
5	Kidney Diseases (Kidney Disease) 04/2016 - 10/2004
5	Colitis 06/2012 - 05/2006
4	Colorectal Neoplasms (Colorectal Cancer) 05/2022 - 09/2017
4	Lymphatic Metastasis 01/2022 - 01/2008
4	Neoplasm Metastasis (Metastasis) 07/2020 - 11/2010
4	Stomach Neoplasms (Stomach Cancer) 09/2019 - 01/2013
4	Disease Progression 05/2012 - 12/2004
4	Membranous Glomerulonephritis (Membranous Nephropathy) 05/2012 - 06/2005
3	Microsatellite Instability 01/2022 - 07/2020
3	Adenocarcinoma 01/2021 - 01/2019
3	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 06/2018
3	Carcinogenesis 04/2019 - 06/2010
3	Hyperglycemia 02/2013 - 01/2005
3	IGA Glomerulonephritis (IGA Nephropathy) 01/2011 - 08/2003
3	Hypertrophy 01/2008 - 01/2005
3	Hypertension (High Blood Pressure) 01/2007 - 05/2002
2	Colonic Neoplasms (Colon Cancer) 05/2022 - 01/2017
2	Prostatic Neoplasms (Prostate Cancer) 01/2014 - 04/2012

Drug/Important Bio-Agent (IBA)

31	nephrinIBA 01/2021 - 01/2002
22	Proteins (Proteins, Gene)FDA Link 12/2020 - 05/2002
15	Messenger RNA (mRNA)IBA 01/2021 - 04/2002
13	Puromycin AminonucleosideIBA 01/2021 - 05/2002
13	Monoclonal AntibodiesIBA 04/2015 - 04/2002
13	NPHS2 proteinIBA 12/2014 - 01/2003
11	Angiotensin IIIBA 10/2016 - 01/2003
7	anti-Thy antibodyIBA 01/2008 - 11/2002
6	CytokinesIBA 03/2016 - 04/2002
6	CreatinineIBA 09/2013 - 08/2005
6	Fibronectins (Fibronectin)IBA 04/2008 - 05/2003
6	Transforming Growth Factor beta1 (TGF beta 1)IBA 02/2008 - 08/2004
5	Pharmaceutical PreparationsIBA 04/2019 - 11/2005
5	Doxorubicin (Adriamycin)FDA LinkGeneric 04/2015 - 05/2002
5	Therapeutic UsesIBA 06/2014 - 11/2002
5	CollagenIBA 06/2012 - 02/2008
4	Keratins (Keratin)IBA 06/2022 - 03/2011
4	Biomarkers (Surrogate Marker)IBA 01/2022 - 02/2014
3	Biological ProductsIBA 08/2022 - 01/2008
3	LigandsIBA 01/2022 - 11/2002
3	Tacrolimus (Prograf)FDA LinkGeneric 01/2022 - 04/2002
3	Complementary DNA (cDNA)IBA 01/2021 - 03/2011
3	Fluorouracil (Carac)FDA LinkGeneric 01/2021 - 01/2013
3	Amyloid (Amyloid Fibrils)IBA 01/2020 - 06/2018
3	Everolimus FDA Link 03/2019 - 01/2008
3	ChemokinesIBA 06/2014 - 08/2006
3	CurcuminIBA 09/2013 - 06/2011
3	Urea (Carbamide)FDA LinkGeneric 09/2013 - 08/2005
3	Transforming Growth Factors (Transforming Growth Factor)IBA 06/2012 - 05/2003
3	Dextran SulfateIBA 06/2012 - 02/2010
3	Collagen Type I (Type I Collagen)IBA 06/2012 - 03/2004
3	Interferon-gamma (Interferon, gamma)IBA 02/2010 - 04/2002
3	Prednisolone (Predate)FDA LinkGeneric 01/2010 - 12/2002
3	DNA (Deoxyribonucleic Acid)IBA 12/2009 - 12/2002
3	Transforming Growth Factor beta (TGF-beta)IBA 04/2008 - 08/2004
2	Calcibiotic Root Canal SealerIBA 08/2022 - 01/2017
2	S100 Proteins (S 100 Protein)IBA 06/2022 - 02/2011
2	Estrogen ReceptorsIBA 05/2022 - 02/2022
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2021 - 08/2019
2	Leucovorin (Folinic Acid)FDA Link 01/2021 - 08/2019
2	Bevacizumab (Avastin)FDA Link 01/2021 - 08/2019
2	Peptides (Polypeptides)IBA 01/2020 - 09/2006
2	Ephrin-B1 (Ephrin B1)IBA 01/2020 - 01/2018
2	Sirolimus (Rapamycin)FDA Link 03/2019 - 02/2008
2	Immune Checkpoint InhibitorsIBA 01/2019 - 01/2018
2	Trastuzumab (Herceptin)FDA Link 11/2018 - 11/2012
2	LeptinIBA 04/2016 - 01/2005
2	Interleukin-10 (Interleukin 10)IBA 04/2015 - 02/2010
2	ParaffinIBA 01/2014 - 09/2012
2	Formaldehyde (Formol)FDA Link 01/2014 - 09/2012
2	NitrogenIBA 09/2013 - 06/2011
2	VimentinIBA 06/2012 - 04/2011
2	DesminIBA 05/2012 - 04/2006
2	Keratin-4 (Keratin 4)IBA 03/2012 - 03/2011
2	Tyrosine (L-Tyrosine)FDA Link 04/2010 - 10/2006
2	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 04/2010 - 02/2007
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2010 - 04/2005
2	GlucocorticoidsIBA 01/2010 - 12/2005
2	SteroidsIBA 01/2010 - 04/2008

Therapy/Procedure

24	Therapeutics 08/2022 - 04/2002
5	Chemoradiotherapy 01/2022 - 03/2017
4	Drug Therapy (Chemotherapy) 08/2022 - 11/2010
4	Neoadjuvant Therapy 01/2022 - 01/2018
3	Nephrectomy 09/2013 - 11/2002
2	Lasers (Laser) 07/2018 - 01/2006